mirnas are endogenous small noncoding rnas that can regulate many cellular processes. different expression levels of several mirnas have been detected in glioblastomas. function of mirnas and targets have been well studied in recent years. according to these studies, the role of mirnas in glioblastoma pathogenesis have been defined. mirnas have affected many processes in gbm such as apoptosis, ...

a young known case of multiple sclerosis was evaluated with chief complaint of gradually progressed left lower limb weakness over 3 weeks. pathologic examination of a mass in brain magnetic resonance imaging confirmed the diagnosis of glioblastoma multiforme (gbm). given the importance of the definite diagnosis of malignant glioma and its effect on patient’s management, gbm should be considered...

the median overall survival in glioblastoma multiforme is usually less than one year. long-term survival is rare and is seen in only 3%-6% of gbm patients. the present study reports the characteristics and treatment outcomes of six cases of glioblastoma multiforme with long-term survival. a literature review is also presented. between 1990 and 2008, 217 glioblastoma multiforme patients have bee...

objective(s): glioblastoma multiforme (gbm) is one of the most lethal forms of human cancer and temozolomide (tmz) is currently part of the standard treatment for this disease. combination therapy using natural substances can enhance the anti-cancer activity of tmz. the purpose of this study was to evaluate the effect of tmz in combination with thymoquinone (tq) on human gbm cell line (u87mg). ...

PURPOSE Glioblastoma multiforme is a deadly primary brain cancer. Because the tumor kills due to recurrences, we tested the hypothesis that a new treatment would lead to immunological memory in a rat model of recurrent glioblastoma multiforme. EXPERIMENTAL DESIGN We developed a combined treatment using an adenovirus (Ad) expressing fms-like tyrosine kinase-3 ligand (Flt3L), which induces the ...

Cell motility and resistance to apoptosis characterize glioblastoma multiforme growth and malignancy. Narciclasine, a plant growth modulator, could represent a powerful new weapon targeting the Achilles' heel of glioblastoma multiforme and may offer the potential to better combat these devastating malignancies. The in vitro effects of narciclasine on cell proliferation, morphology, actin cytosk...

background and objectives: angiogenesis is essential for growth and metastasis of solid malignancies. tumor vessel count and expression of vascular endothelial growth factor (vegf), a potent angiogenic factor, have been associated with prognosis. this study was designed to assess vessels density by using cd31 and cd105 (endoglin) and their correlation with expression of vegf and proliferative i...

PURPOSE There is growing interest in developing cellular immune therapies for glioblastoma multiforme, but little is known about tumor-specific T-cell responses. A glioblastoma multiforme-specific T-cell assay was developed using monocyte-derived dendritic cells to present tumor antigens from the established glioblastoma multiforme cell line U118. EXPERIMENTAL DESIGN Peripheral blood mononucl...

Glioblastoma multiforme is the most aggressive primary brain tumor in adults. Overexpression of the EGF receptor (EGFR) is recognized as a widespread oncogenic signature in glioblastoma multiforme, but the complexity of its contributions is not fully understood, nor the most effective ways to leverage anti-EGFR therapy in this setting. Hypoxia is known to drive the aggressive character of gliob...